Reconsidering Steroids: Origins, Paradox, and the Modern Standard of Care
On September 4, 1948, a bed-ridden 24-year-old woman with rheumatoid arthritis received the first dose of a glucocorticoid. The next morning she could walk. Twenty-three days later, her physicians ...
The Patient Experience of Steroid-toxicity and Shared Decision-making
Thirty-one patients with inflammatory and autoimmune diseases reported more than 100 steroid-related toxicities in a qualitative study published in the Journal of Neurological Sciences in 2024, and ...
Steroid-Toxicity in Children: The Case for a Pediatric GTI
An estimated 10% of children will receive steroids during their childhood. For many, the treatment is life-saving. For far too many, steroids leave a trail of growth inhibition, delayed puberty, mood ...
Mind the Measurement Gap
How health economics and outcomes research (HEOR) puts a value on steroid-toxicity A microsimulation model presented at ISPOR Europe 2025 put a number on the lifetime clinical and economic burden of ...
The Glucocorticoid Toxicity Index: Measuring Change in Trials and Practice
For decades, nearly 70 distinct toxicities have been attributed to long-term glucocorticoid use. Yet, until the Glucocorticoid Toxicity Index (GTI) arrived, clinicians had no standardized, validated ...
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