Mind the Measurement Gap
How health economics and outcomes research (HEOR) puts a value on steroid-toxicity A microsimulation model presented at ISPOR Europe 2025 put a number on the lifetime clinical and economic burden of ...
The Glucocorticoid Toxicity Index: Measuring Change in Trials and Practice
For decades, nearly 70 distinct toxicities have been attributed to long-term glucocorticoid use. Yet, until the Glucocorticoid Toxicity Index (GTI) arrived, clinicians had no standardized, validated ...
From Target Product Profile to Label Value
A drug that costs more than $50,000 per year needs a better argument than "it reduces prednisone by a few milligrams." That argument works if the developer has designed the trial to capture it. Most ...
Why Steroid-Toxicity Must Be Measured: The Clinical and Economic Case
Patients receiving oral steroids for three to four years carry twice the risk of death compared with steroid-naive control groups. That figure comes from a 2022 population-based study of 223,211 oral ...
Three Phase 3 Trials, Three Decisions to Measure Steroid-Toxicity Directly
Patients on long-term steroids for autoimmune and inflammatory diseases know the damage that these drugs cause. The question for sponsors has long been whether a trial can prove it. In June 2026, ...
Curious about the true cost of steroid-toxicity?
Download our infographic today
