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The weekly mean values were calculated based on all recorded systemic (oral or intravenous) glucocorticoid use by all patients in the respective treatment group at the start of each study week.
For each trial participant, patient data was entered into the GTI to generate the Cumulative Worsening Score (CWS), and the Aggregate Improvement Score (AIS), at study weeks 13 and 26. A lower score corresponds to lower toxicity for both indices.
The mean CWS and AIS for all trial participants are both statistically significantly lower for avacopan than for prednisone.
Percentages of patients in ADVOCATE trial exceeding selected Steritas GTI thresholds at week 26